The potent disinfectant action of ozone O3 easily oxidises glycoproteins & lipoproteins. Ozone therapy disrupts the integrity of any bacterial cell envelope through oxidation of the phospholipids and lipoproteins
Ozone attacks lipids, and damages the viral capsid so that the viruses cannot repair that damage. Therefore it upsets the reproductive cycle by disrupting the virus-to-cell contact with peroxidation.
Ozone modulates the immune system through inducing metabolites (ozonites) that create cytokine synthesis such as interferon’s and interleukins which migrate through the lymphoid system.
These cells are then replaced with healthy cells.
This is a very important process because it prevents any virus infection from becoming chronic, bringing the immune system back into balance, allowing the weak enzyme coatings on cells, which are vulnerable to invasion by viruses, to easily oxidize and be elimination from the body.
Stimulation of oxygen metabolism: Ozone therapy causes an increase in the red blood cell glycolysis rate. This leads to the stimulation of 2,3-diphosphoglycerate which leads to an increase in the amount of oxygen released to the tissues. Ozone activates the Krebs cycle by enhancing oxidative carboxylation of pyruvate, stimulating production of ATP. It also causes a significant reduction in NADH and helps to oxidize cytochrome C. There is a stimulation of production of enzymes which act as free radical scavengers and cell-wall protectors: glutathione peroxidase, catalase and superoxide dismutase. Production of prostacyline, a vasodilator, is also induced by O3
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Activation of the immune system: Ozone administered at a concentration of between 30 and 55 μg/cc causes the greatest increase in the production of interferon and the greatest output of tumor necrosis factor and interleukin-2. The production of interleukin-2 launches an entire cascade of subsequent immunological reactions.
Mechanism of action of O3 on the human lung: Ozone exposure induces a significant mean decrement in vital capacity. It significantly increases mean airway resistance and specific airway resistance but does not change dynamic or static pulmonary compliance or viscous or elastic work. It also significantly reduces maximal trans pulmonary pressure. And further more significantly increases respiratory rate and decreased tidal volume.